Cpg Oligodeoxynucleotide by Jesse Russell

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Cpg Oligodeoxynucleotide

Cpg Oligodeoxynucleotide Jesse Russell

Published January 20th 2012

ISBN : 9785510808254


96 pages

High Quality Content by WIKIPEDIA articles! CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine C followed by a guanine G. The p refers to the phosphodiester backbone of DNA, howeverMoreHigh Quality Content by WIKIPEDIA articles! CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine C followed by a guanine G. The p refers to the phosphodiester backbone of DNA, however some ODN have a modified phosphorothioate (PS) backbone. When these CpG motifs are unmethlyated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns (PAMPs) due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher primates.

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Jesse Russell

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